Synovial Membrane Model

The aim of the proposed research project is the integration of a human synovial organ model into a multifunctional lab-on-a-chip to elucidate how systemic stress factors impart architectural remodeling of the synovial tissue.
We hypothesize that the reorganization of the synovium that takes place in arthritis is intimately linked to altered tissue functions in support of the perpetuation of inflammation  as well as joint destruction. To date no work has systematically addressed the interdependence between tissue reorganization and tissue function. The successful cultivation of a complex living system in a microanalytical analysis platform would therefore yield substantial insights into rheumatoid arthritis pathogenesis and open new avenues for exploring the mechanisms of inflammation-induced tissue fibrosis
and organ failure.